AcroVoice: the controversial values in reflecting acromegaly disease activity

Source: Pituitary - Category: Endocrinology Source Type: research

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CONCLUSION: These data demonstrate that high-dose Sandostatin LAR as monotherapy or in combination with pegvisomant or cabergoline is a feasible salvage option in patients with pituitary adenomas not adequately controlled on conventional SSA regimens. PMID: 31274183 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
Pituitary adenomas are a rare but important central nervous system tumor in children. Because of differences in growth and development, the manifestations of pituitary adenomas in children may differ from those seen in adults. Unlike adult patients, the pediatric population more often presents with clinically secretory adenomas. Although medical management is first-line treatment of prolactinomas, transsphenoidal surgery is appropriate for most children with Cushing disease and gigantism. Although some pediatric patients present surgical challenges because of small anatomic dimensions or an incompletely developed sphenoid ...
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
Condition:   Acromegaly Intervention:   Sponsor:   Ipsen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Interdisciplinary Management of Sellar Masses Abstract. Sellar masses may present with an impairment of pituitary function (hypopituitarism), hormone hypersecretion (prolactinoma, acromegaly, glucocorticoid excess) or neurological symptoms (visual impairment, headache). An increasing number of them is discovered as an incidentaloma. Among the various entities, benign pituitary adenomas and cystic lesions are most frequently encountered. The work-up includes a laboratory evaluation for hormone hyper- or hyposecretion and an MRI of the pituitary gland. If the optic chiasm is compromised, a visual field exam...
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
ConclusionsAlthough it rarely reveals CNC, acromegaly is diagnosed at a younger age in this setting, with a higher proportion of microadenomas.
Source: Pituitary - Category: Endocrinology Source Type: research
Conclusions: This radiomics model can assist neurosurgeons in predicting the tumor consistency in patients with acromegaly before surgery and facilitate the determination of individualized therapeutic schemes.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this paper, the authors provide recommendations regarding the appropriate use of pasireotide long-acting release in the treatment of acromegaly.Journal of Clinical Endocrinology &Metabolism
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Diabetes & Endocrinology Journal Article Source Type: news
AbstractNeurocognitive and psychological dysfunctions associated with pituitary adenomas (PAs) are clinically relevant, though probably under-reported. The aim of the current review is to provide an update on neuropsychological status, psychopathology, and perceived quality of life (QoL) in patients with PAs. A systematic research was performed in PubMed and Scopus in order to identify reports on neurocognitive, psychiatric, and psychological disorders in PAs. Prevalence of alterations, QoL evaluation, and used tests were also recorded. PRISMA guidelines were followed. Of 62,448 identified articles, 102 studies were includ...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Acromegaly results in a significantly increased morbidity and mortality due to cardiovascular and respiratory complications as well as malignancies arising mainly from the colon. Furthermore, an increased lifetime risk of malignant transformation of pre-malignant colonic lesions relates to a worse overall prognosis from colorectal cancer, which is currently considered a major disease related complication. In this review we provide some insight into colonic changes in this condition, summarise current knowledge and evidence on the use of colonoscopic screening in patients with acromegaly, and suggest a recommended screening protocol.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
AbstractPurposeThe increased life expectancy in the general population is causing rapid growth of the number of elderly patients. Pituitary adenomas (PAs) are one of those tumors whose incidence increases with age. Pituitary surgery in elderly has usually been considered riskier than in the younger population. The aim of this study was to evaluate the surgical outcome of a large series of patients who underwent transsphenoidal surgery for PAs.MethodsWe retrospectively reviewed a series of patients who underwent transsphenoidal surgery for PAs in our institution. Inclusion criteria were: 65 years of age or more, and no prev...
Source: Endocrine - Category: Endocrinology Source Type: research
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