A Single-Center Retrospective Study of Patients with Double Primary Cancers: Breast Cancer and < b > < i > EGFR < /i > < /b > -Mutant Non-Small Cell Lung Cancer

Background: Second primary malignancies (SPM) in the lung are not common in breast cancer (BC) patients.EGFR-mutant lung cancer (LC) is a separate molecular subset, and the co-existence ofEGFR-mutant LC and BC has not been explored. We hypothesized thatEGFR-mutant LC patients could have higher rates of primary BC than those withEGFR-wild type (WT).Methods: We collected data on clinical and molecular characteristics and outcomes of female patients with LC and a previous or simultaneous history of primary BC treated in our hospital from 2008 to 2014.Results: Data on treatment, follow-up, andEGFR mutation status were available for 356 patients. 17.7% (11/62) of patients withEGFR mutations had BC, compared to 1.02% (3/294) ofEGFR-WT patients (p
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research