Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site

ConclusionsThese studies suggest that the binding properties of [18F]AV-1451 and [18F]THK5351 are sufficient to expect highlighting of tissues with a high density of MCCs. The findings of the present study should aid the development of neuroimaging ligands that do not bind to MCC.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research