Repeated potassium iodide exposure during pregnancy impairs progeny’s brain development

Publication date: Available online 21 February 2019Source: NeuroscienceAuthor(s): Dalila LEBSIR, Julien GUEMRI, Dimitri KERESELIDZE, Stephane GRISON, Marc BENDERITTER, Annick PECH, David COHEN, Mohamed Amine BENADJAOUD, Philippe LESTAEVEL, Maâmar SOUIDIAbstractProtracted radioiodine release, may requires repeated intake of potassium iodide (KI) to protect thyroid gland. It is well established that iodine excess inhibits transiently the thyroid function. As developing foetus depends on maternal thyroid hormones (TH) supply, more knowledge are needed about the plausible effects that repeated KI intake can cause in this sensitive population, especially that even subtle variation of maternal thyroid function may have persistent consequences on progeny brain processing. The aim of this study is to assess the consequences of repeated intake of KI during pregnancy on the progeny's thyroid function and brain development. To do so pregnant Wistar rats received KI over eight days, and then thirty days after the weaning, male progeny was subjected to behaviour test. Pituitary and thyroid hormones level, anti-thyroid antibodies level, organs morphology, genes expression and global DNA methylation were assessed. Thirty days after the weaning, KI-exposed male progeny showed an uncommon hormonal status, characterized by a decrease of both TSH (− 28%) and FT4 (− 7%) levels. Motor coordination was altered in KI-exposed male progeny, at the cerebellar level we observed a decreas...

Source: Neuroscience - February 22, 2019 Category: Neuroscience Source Type: research