Viruses, Vol. 11, Pages 190: Novel Approaches for The Development of Live Attenuated Influenza Vaccines

Viruses, Vol. 11, Pages 190: Novel Approaches for The Development of Live Attenuated Influenza Vaccines Viruses doi: 10.3390/v11020190 Authors: Pilar Blanco-Lobo Aitor Nogales Laura Rodríguez Luis Martínez-Sobrido Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines. Vaccination with traditional inactivate influenza vaccines (IIV) or live-attenuated influenza vaccines (LAIV) remains the main strategy in the control of annual seasonal epidemics, but it does not offer protection against new influenza viruses with pandemic potential, those that have shifted. Moreover, the continual antigenic drift of seasonal circulating influenza viruses, causing an antigenic mismatch that requires yearly reformulation of seasonal influenza vaccines, seriously compromises vaccine efficacy. Therefore, the quick optimization of vaccine production for seasonal influenza and the development of new vaccine approaches for pandemic viruses is still a challenge for the prevention of influenza infections. Moreover, recent reports have questioned the effectiveness of the current LAIV because of limited protection, mainly against the influenza A virus (IAV) component of the vaccine. Although the reasons for the poor protection efficacy of the LAIV have not yet been elucidated, researchers are encouraged to develop new vaccination approaches that overcome the limitations that are associated...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research