Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development

This study reveals another role for hemodynamic force in regulating blood vessel development of the mouse, and opens up a new model to begin elucidating mechanotransduction pathways regulating vascular maturation.Graphical abstractIn normal flow embryos, vascular maturation occurs by the recruitment of vSMCs in the mesoderm to blood vessels exposed to high flow. This is followed by the attachment of the vSMCs to the high-flow vessels. In reduced-flow embryos, the vessels are exposed to lower flow, which minimizes the amount of recruited vSMCs towards any particular vessel.

Source: Mechanisms of Development - February 22, 2019 Category: Biology Source Type: research