High Information Content Assays for Genetic Toxicology Testing: A Report of the International Workshops on Genotoxicity Testing (IWGT)

Publication date: Available online 21 February 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Stephen D. Dertinger, Yukari Totsuka, Jason H. Bielas, Ann T. Doherty, Jos Kleinjans, Masamitsu Honma, Francesco Marchetti, Maik J. Schuler, Veronique Thybaud, Paul White, Carole L. YaukAbstractWe live in an era of ‘big data’, where the volume, velocity, and variety of the data being generated is increasingly influencing the way toxicological sciences are practiced. With this in mind, a workgroup was formed for the 2017 International Workshops on Genotoxicity Testing (IWGT) to consider the use of high information content data in genetic toxicology assessments. Presentations were given on adductomics, global transcriptional profiling, error-reduced single-molecule sequencing, and cellular phenotype-based assays, which were identified as methodologies that are relevant to present-day genetic toxicology assessments. Presenters and workgroup members discussed the state of the science for these methodologies, their potential use in genetic toxicology, current limitations, and the future work necessary to advance their utility and application. The session culminated with audience-assisted SWOT (strength, weakness, opportunities, and threats) analyses. The summary report described herein is structured similarly. A major conclusion of the workgroup is that while conventional regulatory genetic toxicology testing has served the public well over th...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research