Assessing suitability for sacubitril-valsartan therapy in an Irish cohort: challenges and opportunities

ConclusionsOur study showed that a smaller than expected proportion of our patients in real-world practice are suitable for sacubitril-valsartan therapy at discharge. Most patients were in the HFPEF cohort which does not currently have evidence for treatment with sacubitril-valsartan. Low rates of prescribing of basic heart failure medicatons and the absence of dedicated heart failure services in a non-tertiary centre may explain the poor compliance observed. Improving guideline adherence and increasing awareness of evidence-based medication use at primary and secondary care levels would be of benefit to Irish heart failure patients.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research

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Authors: Ouyang Q, You T, Guo J, Xu R, Guo Q, Lin J, Zhao H Abstract Apelin plays important roles in cardiovascular homeostasis. However, its effects on the mechanoenergetics of heart failure (HF) are unavailable. We attempted to investigate the effects of apelin on the left ventricular-arterial coupling (VAC) and mechanical efficiency in rats with HF. HF was induced in rats by the ligation of the left coronary artery. The ischemic HF rats were treated with apelin or saline for 12 weeks. The sham-operated animals served as the control. The left ventricular (LV) afterload and the systolic and diastolic functions, as...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
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