Aggravation of cardiac myofibroblast arrhythmogeneicity by mechanical stress

Conclusions The findings demonstrate that both constitutive and strain-induced activity of MSCs in MFBs significantly enhance their depolarizing effect on electrotonically coupled CMCs. Ensuing aggravation of slow conduction may contribute to the precipitation of strain-related arrhythmias in fibrotically remodelled hearts.

http://cardiovascres.oxfordjournals.org/cgi/content/short/104/3/489?rss=1

Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Grand, T., Salvarani, N., Jousset, F., Rohr, S. Tags: Ion channels and arrhythmias Source Type: research