Hypotonic swelling promotes nitric oxide release in cardiac ventricular myocytes: impact on swelling-induced negative inotropic effect

Conclusions Our findings suggest a novel mechanism for NO release in cardiomyocytes with putative pathophysiological relevance determined, at least in part, by its capability to reduce the extent of contractile dysfunction associated with hypotonic swelling.

http://cardiovascres.oxfordjournals.org/cgi/content/short/104/3/456?rss=1

Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Gonano, L. A., Morell, M., Burgos, J. I., Dulce, R. A., De Giusti, V. C., Aiello, E. A., Hare, J. M., Vila Petroff, M. Tags: Cardiac biology and remodelling Source Type: research