Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes

Conclusion
This study identifies a previously unknown function of Krox20 during heart valve development. These results indicate that Krox20-mediated activation of fibrillar Col1a1 and Col3a1 genes is crucial to avoid postnatal degeneration of the AoV leaflets.

Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Odelin, G., Faure, E., Kober, F., Maurel-Zaffran, C., Theron, A., Coulpier, F., Guillet, B., Bernard, M., Avierinos, J.-F., Charnay, P., Topilko, P., Zaffran, S. Tags: Cardiac biology and remodelling Source Type: research