FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry

Conclusion FGF10 regulates regional cardiomyocyte proliferation in the foetal heart through a FOXO3/p27kip1 pathway. In addition, FGF10 triggers cell-cycle re-entry of adult cardiomyocytes and is thus a potential target for cardiac repair.

http://cardiovascres.oxfordjournals.org/cgi/content/short/104/3/432?rss=1

Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Rochais, F., Sturny, R., Chao, C.-M., Mesbah, K., Bennett, M., Mohun, T. J., Bellusci, S., Kelly, R. G. Tags: Cardiac biology and remodelling Source Type: research