E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression
Conclusion
E2F1 limits cardiac neovascularization and functional recovery after MI by suppressing VEGF and PlGF up-regulation through p53-dependent and -independent mechanisms, respectively.
Source: Cardiovascular Research - Category: Cardiology Authors: Wu, M., Zhou, J., Cheng, M., Boriboun, C., Biyashev, D., Wang, H., Mackie, A., Thorne, T., Chou, J., Wu, Y., Chen, Z., Liu, Q., Yan, H., Yang, Y., Jie, C., Tang, Y.-L., Zhao, T. C., Taylor, R. N., Kishore, R., Losordo, D. W., Qin, G. Tags: Cardiac biology and remodelling Source Type: research