ACMSD: A Novel Target for Modulating NAD+ Homeostasis

Publication date: Available online 21 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jun YoshinoNAD+ has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD+ metabolism and overexpression of human ACMSD leads to niacin dependency for NAD+ biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD+ deficiency.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research