Predictors of Radiation-Induced Liver Disease in Eastern and Western Patients with Hepatocellular Carcinoma Undergoing Proton Beam Therapy

The optimal dose-volumetric indices to prevent radiation-induced liver disease (RILD) remain unclear in hepatoma patients undergoing proton beam therapy (PBT). This multi-institutional study demonstrated the unirradiated liver volume to standard liver volume ratio (ULV/SLV) as the most crucial RILD predictor. Distinct from photon radiotherapy, mean liver dose is not an independent RILD determinant. Our results indicate that doses ≥1 GyE could cause hepatic complications, and preserving sufficient ULV/SLV is imperative to prevent RILD in PBT.

Source: International Journal of Radiation Oncology * Biology * Physics - February 21, 2019 Category: Radiology Authors: Cheng-En Hsieh, Bhanu Prasad Venkatesulu, Ching-Hsin Lee, Sheng-Ping Hung, Pei-Fong Wong, Sathvik Panambur Aithala, Byung Kyu Kim, Arvind Rao, Joseph Tung-Chieh Chang, Ngan-Ming Tsang, Chun-Chieh Wang, Chung-Chi Lee, Chen-Chun Lin, Jeng-Hwei Tseng, Wen-Ch Tags: Clinical Investigation Source Type: research