Phenotype-Oriented Ablation of Oligometastatic Cancer With Single Dose Radiotherapy

Inherent biological drivers of the oligometastatic (OM) state determine conversion to polymetastatic (PM) dissemination over the impact of effective OM ablation by ultra-high dose radiotherapy. Baseline volumetric and metabolic OM metrics derived from PET/CT scanning before radioablation predict long-term PM conversion post-ablation, categorizing diverse OM phenotypes by susceptibility to PM conversion. The PET/CT platform provides guidelines for phenotype-driven OM therapy and promotes discovery of tractable PM conversion drivers as targets for new experimental treatments.

Source: International Journal of Radiation Oncology * Biology * Physics - February 21, 2019 Category: Radiology Authors: Carlo Greco, Oriol Pares, Nuno Pimentel, Vasco Louro, Javier Morales, Beatriz Nunes, Joana Castanhera, Carla Oliveira, Angelo Silva, Sofia Vaz, Durval Costa, Michael Zelefsky, Richard Kolesnick, Zvi Fuks Tags: Clinical Investigation Source Type: research