(2S,4R)-4-[ 18 F]Fluoroglutamine as a PET Indicator for Bone Marrow Metabolism Dysfunctional: from Animal Experiments to Clinical Application

ConclusionsDissection experiments in mice showed that [18F]GLN displayed relatively high bone marrow uptake, and the uptake was sensitive to bone marrow inhibition induced by doxorubicin/rituximab. The same conclusion was confirmed [18F]GLN/PET imaging in humans. Therefore, [18F]GLN/PET imaging may be a useful tool to assess reduction of bone marrow activity in cancer patients, who may be at risk of myelosuppression after chemotherapy.Trial RegistrationApproved by Institutional Review Board of Peking University Cancer Hospital (No. 2017KT38). Registered 18 August 2017.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research