Combination of exercise and calorie restriction exerts greater efficacy on Cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation

Long-term high-fat diet (HFD) consumption causes obese-insulin resistance which is known to be a major risk factor for cardiovascular diseases due to its impact on the impairment of left ventricular (LV) contractile function and cardiac mitochondrial function. Intracellular calcium [Ca2+]i regulation plays an important role in the maintenance of LV function. Although either caloric restriction (CR) or exercise (Ex) are shown to strongly affect metabolic status and LV function, the combined effects of exercise and calorie restriction on cardiometabolic status, cardiac mitochondrial dynamics and cardiac [Ca2+]i transient homeostasis under conditions of obese-insulin resistance have never been investigated.

Source: Metabolism - Clinical and Experimental - February 21, 2019 Category: Biomedical Science Authors: Siripong Palee, Wanitchaya Minta, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Siriporn C. Chattipakorn, Nipon Chattipakorn Source Type: research