Outcomes after salvage radical prostatectomy and first-line radiation therapy or HIFU for recurrent localized prostate cancer: results from a multicenter study

ConclusionssRP was safe, feasible, and effective using either an open or robot-assisted approach, in experienced hands. Age, preoperative clinical stage, NS procedure, and pathological GS were linked with BCR after sRP.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research

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Authors: Latorzeff I Abstract Prostate cancer is a sensitive adenocarcinoma, in more than 80 % of cases, to chemical castration, due to its hormone dependence. Locally advanced and/or high-risk cancer is defined based on clinical stage, initial PSA value or high Gleason score. Hormone therapy associated with radiation therapy is the standard of management and improves local control, reduces the risk of distant metastasis and improves specific and overall survival. Duration of hormone therapy, dose level of radiation therapy alone or associated with brachytherapy are controversial data in the literature. Radical pro...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Authors: Houédé N Abstract To date, systemic treatments, including hormone therapies or chemotherapy, are used at different stages of prostate cancer disease. Several types of complications can occur during systemic treatment in prostate cancer, depending on the therapeutic range. The most common with hormone therapy are fatigue, muscle loss, bone loss, high blood pressure and metabolic syndromes. For chemotherapy, the most significant risk is related to hematological toxicity, but peripheral neuropathies, mucositis, diarrhea and hypersensitivity reactions may also occur. The quality of the pre-treatm...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
In conclusion, multimodal regimens increase the risk of side effects compared to surgery or radiotherapy alone. Indications of these approaches muste be discussed with the patients after a careful evaluation of the benefit/risk ratio. PMID: 31307629 [PubMed - in process]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
CONCLUSION: In absence of consensus or guidelines, management of prostate cancer should be an individualized, patient-based management taking into account primary tumor stage and grade, number and types of metastasis and patient characteristics. PMID: 31307628 [PubMed - in process]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Authors: Erra B, Pradere B Abstract Nuclear medicine is a keystone specialty in the evaluation and management of prostate cancer. Its recent development, particularly through metabolic imaging and isotope therapy, has made it a major gamechanger in the management of metastatic prostate cancer. The aim of this article was to postpone its place within the various stages of the disease through a comprehensive review of national and international recommendations. PMID: 31307627 [PubMed - in process]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Xue-Long Yan, Jun-Sheng Zhang, Jia-Luo Huang, Yao Zhang, Jia-Qi Chen, Gui-Hua Tang, Sheng YinAbstractSeven previously undescribed polycyclic diterpenoids, euphonoids A−G, including four ent-abietanes, two ent-atisanes, and one ent-kaurene, along with 26 known analogues were isolated from the roots of Euphorbia fischeriana. The structures of the undescribed compounds were elucidated by spectroscopic analysis, ECD calculations, and single crystal X-ray diffraction. Besides, the structure of a previously reported ent-abietane diterpenoid, fischer...
Source: Phytochemistry - Category: Chemistry Source Type: research
Guidance for Industry
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
In conclusion, Denosumab administration can be considered effective and safe in the prevention and management of the above mentioned adverse events related to hormonal therapies designed for breast and prostate tumors.
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Contributors : Mark P Labrecque ; Ilsa M Coleman ; Lisha G Brown ; Lawrence D True ; Lori Kollath ; Bryce Lakely ; Holly M Nguyen ; Yu C Yang ; Arja H Kaipainen ; Roger T Coleman ; Celestia S Higano ; Evan Y Yu ; Heather H Cheng ; Elahe A Mostaghel ; Bruce Montgomery ; Michael T Schweizer ; Andrew C Hsieh ; Daniel W Lin ; Eva Corey ; Peter S Nelson ; Colm MorrisseySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe widespread and long-term use of potent therapies designed to repress androgen receptor (AR) signaling is changing the molecular and phenotypic landscapes of prostate cancer...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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