Antimicrobial and anti-biofilm properties of novel synthetic lignan-like compounds.

Antimicrobial and anti-biofilm properties of novel synthetic lignan-like compounds. New Microbiol. 2019 Feb 20;42(1) Authors: Vollaro A, Catania MR, Iesce MR, Sferruzza R, D'Abrosca B, Donnarumma G, De Filippis A, Cermola F, DellaGreca M, Buommino E Abstract Antibiotic resistance and biofilm tolerance are among the principal factors involved in the persistence of chronic infections. The need for new antimicrobials is an ever-increasing challenge in clinical environments and in the control of global health. Arylfurans form a set of structures that have been identified in many natural products, e.g. lignans. Lignans are a sub-group of non-flavonoid polyphenols that play an active role in plants' defense against bacteria and fungi infections. The aim of this study was to identify novel synthetic arylfurans and lignan-like arylbenzylfurans exhibiting antimicrobial properties. The molecules synthetized were tested against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and S. epidermidis. We found that among tested compounds, arylbenzylfuran 11 was active against S. aureus and S. epidermidis with an MIC of 4 μg ml-1. Compound 11 was also active on methicillin-resistant S. aureus and S. epidermidis. By confocal laser scanning microscopy, we showed that 32 μg ml-1 of compound 11 was able to induce a significant reduction in S. aureus and S. epidermidis biofilms viability. Finally, we demonstrated that compound 11 was not c...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research