Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

ConclusionSeveral differences in gene expression with respect to HBV genotype A and C infection were detected in human hepatocytes. These differences might be associated with genotypic difference in the clinical course or responsiveness to treatment.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research

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Conclusion: A significant proportion of pregnant women have anti-HBs while the seroprevalence of HCV is low among pregnant women in the city of Mwanza. Routine screening of HBV among pregnant women coupled with appropriate management should be emphasized in developing countries. Further studies to determine seroprevalence of HCV are recommended across the country. PMID: 31316835 [PubMed - in process]
Source: Journal of Pregnancy - Category: OBGYN Tags: J Pregnancy Source Type: research
Authors: Lv LL, Yang YX, Shi TD Abstract There are two main types of drugs that are used to treat chronic hepatitis B (CHB), including interferon (IFN) and nucleotide analogues. IFN inhibits the virus through direct antiviral activity and via immune regulation, and it has been widely applied for the treatment of CHB and other infections. However, the efficiency of IFN therapy is not entirely satisfactory. The aim of the present study was to investigate the factors affecting IFN therapy. The plasma of patients with CHB treated with IFN was collected and divided into the virological response group and non-virological...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Conclusion: NAFLD is emerging as a predominant etiology of CLD in India, followed by ALD, HBV, and HCV. However, significant regional differences regarding predominant etiology was noted within the country. It was further noted that significant number of patients had advanced fibrosis based on VCTE assessment. This study emphasizes the need for appropriate risk evaluation and early assessment of severity of liver disease, for adequate disease management. PMID: 31315327 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: To conclude, the study highlights good knowledge about hepatitis B infection with requirement of more emphasis on the practical aspects of management in a case of NSI/blood splash and can guide to improve the vaccination status and knowledge of HBI amongst HCWs. PMID: 31315320 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
[Monitor] In 2016, deaths caused by viral hepatitis surpassed all chronic infectious diseases, including HIV/Aids, malaria and tuberculosis, according to a Global Burden of Disease study. The prevalence of hepatitis B in Uganda stands at 4.1 per cent, which means that 1.75 million people are infected. This is according to a study carried out by the Ministry of Health in partnership with the Centre for Disease Control (CDC) and the World Health Organisation (WHO).
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
In this study, an anti-HBV mathematical model is considered and its control strategy of the drug treatment is designed. Based on the Lyapunov theory, this study derives three main theorems to propose three different control strategies, respectively, for drug treatments $mlpar trpar $m(t) and $nlpar trpar $n(t), such that all states of the anti-HBV model can finally converge to the infection-free equilibrium point $E_1$E1 asymptotically. Especially, the designed drug treatment $mlpar trpar $m(t) or $nlpar trpar $n(t) is not a fixed value, but it is time-varying and dependent on states. In Theorem 1, the single drug treatmen...
Source: IET Systems Biology - Category: Biology Source Type: research
Authors: Köksal AS, Toka B, Eminler AT, Hacıbekiroğlu I, Sunu C, Uslan MI, Karabay O, Parlak E Abstract BACKGROUND AND AIM: Hepatitis B Virus (HBV) screening before starting immunosuppressive treatment is of vital importance in order to prevent HBV reactivation and its associated clinical consequences. Despite all recommendations by international organizations, screening rates are far below desired. The aim of this study was to assess the efficacy of a computer alert programme 'HBVision' for increasing HBV screening rates. MATERIAL AND METHODS: 'HBVision' identifies patients at risk of HBV reactivation b...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Authors: Kara AV, Yıldırım Y, Ozcicek F, Aldemir MN, Arslan Y, Bayan K, Çelen MK Abstract BACKGROUND AND STUDY AIMS: The aim of this study was to enlighten the controversy about the renal safety of entecavir, tenofovir, and telbivudine treatments in chronic hepatitis B (CHB) patients by comparing these treatments in real-world conditions. PATIENTS AND METHODS: We retrospectively enrolled 104 treatment-naive patients with CHB monoinfection into our study. Patients were treated with entecavir monotherapy (n=38), tenofovir monotherapy (n=35), or telbivudine monotherapy (n=31). We then compared and statis...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Authors: Chou JW, Lai HC, Chang CH, Cheng KS, Feng CL, Chen TW Abstract The incidence and prevalence of inflammatory bowel disease (IBD) are low but increasing in Taiwan. We aimed to investigate the epidemiology and clinical outcomes of IBD in central Taiwan. We retrospectively analyzed patients with IBD diagnosed at our hospital between January 2000 and September 2018. The diagnostic criteria were based on endoscopic and pathologic findings. Clinical characteristics, treatment regimens, and treatment outcomes were analyzed. A total of 190 patients with IBD were enrolled (80 with Crohn's disease (CD) and 110 with u...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
ConclusionsOur prospective study performed in a real-world setting showed a high immunogenicity and safety of HBV-AS04 vaccine in patients with CKD not yet on maintenance dialysis. Studies provided with longer follow-ups are under way to assess the durability of seroprotection in responders.
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
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