Monocrotaline pyrrole induces pulmonary endothelial damage through binding to and release from erythrocytes in lung during venous blood reoxygenation.

In conclusion, our results demonstrate the importance of oxygen partial pressure on monocrotaline pyrrole binding to erythrocytes and on aggregation and injury of pulmonary endothelial cells. We suggest that these mechanisms contribute to pulmonary selectivity of this toxic injury model of pulmonary hypertension. PMID: 30785344 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30785344?dopt=Abstract

Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - February 20, 2019 Category: Cytology Authors: Xiao R, Zhu L, Su Y, Zhang J, Lu Y, Li J, Wang T, Fang J, Jing ZC, Dupuis J, Luo S, Hu Q Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research