Evaluation of serum cancer antigen 125, resistin, leptin, homocysteine, and total antioxidant capacity in rat model of endometriosis treated with Curcumin

This study explores the changes of serum levels of Cancer Antigen 125 (CA125), leptin, resistin, homocysteine, and total antioxidant capacity (TAC) in a rat model of endometriosis and the effect of curcumin treatment on these factors. F ifty female Sprague‐Dawley rats (220–250 gr body weight) were randomly divided into control (received 0.3 mL of the vehicle), sham(stress of surgery + 0.3 mL of the vehicle) and three endometriosis groups as danazol treatment (7.2 mg/kg BW, IP), curcumin treatment (48 mg/kg BW, IP) and te st (received 0.3 mL of the vehicle). Endometriosis was induced by surgically auto‐transplantation of uterine tissue to the abdominal wall and intestinal mesentery. The animals were treated for 4 weeks. On the last day, the blood sample was collected by heart puncture, and the above‐mentioned f actors were measured in the sera. Leptin in the curcumin treatment group was markedly higher than all of the studied groups, except the danazol group, while there were no significant differences between other groups (P <  0.05). Level of resistin in endometriosis groups did not show significant differences with the control group (P <  0.05). There was no significant difference in the serum levels of homocysteine and CA 125 between all of the studied groups (P >  0.05). The serum levels of TAC in the control group were significantly higher than all of the studied groups (P <  0.05). Curcumin could prevent the growth of endometriosis, ...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research