Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon

AbstractPurpose of ReviewStudies in humans and animal models show that most recovery from impairment occurs in the first 1 –3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short-lived “sensitive period” of post-stroke plasticity defined by unique genetic, physiological, and st ructural events. Unfortunately, rehabilitative interventions in humans have not been able to exploit this sensitive period similar to that seen in animal models. Here, we review these data and suggest a path forward.Recent FindingsPre-clinical data reveal underlying mechanisms that define the post-stroke sensitive period. These data are then discussed in the context of the spontaneous post-stroke recovery described in humans.SummaryFuture work will need to capitalize on unique interactions between the sensitive period, spontaneous recovery, and novel types of rehabilitative interventions.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research