Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice.

CONCLUSION: The knockout of Claudin-7 in vivo causes extensive inflammation, atypical hyperplasia, and adenoma in intestinal tissue as well as animal death in mice. Claudin-7 may act as a tumor suppressor gene in the development of colorectal cancer.
PMID: 30774273 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Xu C, Wang K, Ding YH, Li WJ, Ding L Tags: World J Gastroenterol Source Type: research