Viruses, Vol. 11, Pages 171: Influenza Virus Infections and Cellular Kinases
Viruses, Vol. 11, Pages 171: Influenza Virus Infections and Cellular Kinases
Viruses doi: 10.3390/v11020171
Authors:
Robert Meineke
Guus F. Rimmelzwaan
Husni Elbahesh
Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 subtypes, which pose a threat to public health. Treatment options are limited and emergence of strains resistant to antiviral drugs jeopardize this even further. Like all viruses, IAVs depend on host factors for every step of the virus replication cycle. Host kinases link multiple signaling pathways in respond to a myriad of stimuli, including viral infections. Their regulation of multiple response networks has justified actively targeting cellular kinases for anti-cancer therapies and immune modulators for decades. There is a growing volume of research highlighting the significant role of cellular kinases in regulating IAV infections. Their functional role is illustrated by the required phosphorylation of several IAV proteins necessary for replication and/or evasion/suppression of the innate immune response. Identified in the majority of host factor screens, functional studies further support the important role of kinases and their potential as host restriction factors. PKC, ERK, PI3K a...
Source: Viruses - Category: Virology Authors: Robert Meineke Guus F. Rimmelzwaan Husni Elbahesh Tags: Review Source Type: research
More News: Bird Flu | Cancer | Cancer & Oncology | Cancer Therapy | Epidemics | Epidemiology | Flu Pandemic | H5N1 | Influenza | International Medicine & Public Health | Outbreaks | Pandemics | Respiratory Medicine | Study | Virology | Zoonoses