Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury

Persistent injury of the hepatic tissue leads to fibrosis, which eventually evolves to cirrhosis, the end-stage of any chronic liver diseases. Cirrhosis is characterized by distortion of hepatic architecture, regenerative nodules and hepatocyte dysfunction and is associated with life-threatening complications such as hepatocellular insufficiency and hepatocellular carcinoma (HCC)[1]. Liver cirrhosis is estimated to cause around 170,000 deaths annually[2]. So far, liver transplantation represents the only curative therapeutic solution for many chronic liver diseases.

Source: Journal of Hepatology - February 19, 2019 Category: Gastroenterology Authors: Rita Manco, Laure-Alix Clerbaux, Stefaan Verhulst, Myriam Bou Nader, Christine Sempoux, Jerome Ambroise, Bertrand Bearzatto, Jean Luc Gala, Yves Horsmans, Leo van Grunsven, Chantal Desdouets, Isabelle Leclercq Tags: Research Article Source Type: research