One-step fabrication of boronic-acid-functionalized carbon dots for the detection of sialic acid.

In this study, a novel approach for preparing fluorescent boronic-acid-modified carbon dots (C-dots) for the detection of SA was developed. The functionalized C-dots were synthesized by a facile, one-step hydrothermal method using 3-pyridineboronic acid as the sole carbon source. The added SA selectively recognized the C-dots, leading to the fluorescence quenching of the C-dots in a linear range of 80-4000 μM with a detection limit of 54 μM. The as-developed boronic-acid nanoprobe was successfully applied for the detection of SA in human serum samples with satisfactory results. In addition, this method afforded results within 4 min. Compared to other methods, this new proposed approach was simpler and exhibited excellent sensitivity and selectivity, demonstrating immense potential as an alternative for SA detection.
PMID: 30771974 [PubMed - in process]

Source: Talanta - February 19, 2019 Category: Chemistry Authors: Xu S, Che S, Ma P, Zhang F, Xu L, Liu X, Wang X, Song D, Sun Y Tags: Talanta Source Type: research