Patient safety alert: omission or delay of desmopressin

Patient safety alert: Risk of severe harm or death when desmopressin is omitted or delayed in patients with cranial diabetes insipidus A stage one patient safety alert has been issued by NHS Englan
Source: Royal Pharmaceutical Society News - Category: Drugs & Pharmacology Source Type: news

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ConclusionOverinflation of the balloon during ETV and subsequent hypothalamic injury can cause DI, a rare but potentially dangerous complication of this procedure. Postoperative surveillance and management of electrolytes disturbances is crucial to prevent any long term injury. ETV must be reconsidered if the prepontine cistern is not clearly patent to avoid complications.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Conclusion: SACs are rare with no consensus on the indications for surgery. Our experience suggests that fenestration of SAC through transcranial approach is a valid option for patients with visual deficit and/or pituitary dysfunction. PMID: 31966929 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibuloocculomotor testing due to nausea and visual straining. Cranial computed tomography/magnetic resonance imaging was unremarkable. Laboratory testing revealed critically low serum cortisol, hypernatremia, and urine studies suggesting diabetes insipidus. The patient was referred to the emergency department. Intravenous fluid resuscitation, corticos...
Source: Current Sports Medicine Reports - Category: Sports Medicine Tags: Case Report Source Type: research
Abstract A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibuloocculomotor testing due to nausea and visual straining. Cranial computed tomography/magnetic resonance imaging was unremarkable. Laboratory testing revealed critically low serum cortisol, hypernatremia, and urine studies suggesting diabetes insipidus. The patient was referred to the emergency department. Intravenous fluid resus...
Source: Current Sports Medicine Reports - Category: Sports Medicine Authors: Tags: Curr Sports Med Rep Source Type: research
by Michael Fralick, Sebastian Schneeweiss, Christopher J. D. Wallis, Emily H. Jung, Aaron S. Kesselheim BackgroundDesmopressin was approved by the Food and Drug Administration (FDA) in 1978 for use in diabetes insipidus and bleeding disorders, but it is also prescribed off-label for patients with nocturia. Quantifying the potential risks facing adult patients taking desmopressin has taken on added importance because a new intranasal formulation of desmopressin was approved by the FDA in 2017. Like the old formulation, the main active ingredient is desmopressin acetate, but the new formulation also contains an excipient des...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Abstract Orbital apex syndrome (OAS) manifests as multiple cranial nerve palsies caused by an abnormal nerve response to inflammation or other processes. Central diabetes insipidus (CDI) is characterized by deficient synthesis or secretion of antidiuretic hormone. A 62-year-old woman underwent myringotomy for otitis media with effusion. Two months after the procedure, symptoms of hearing loss had not improved, and she underwent left tympanoplasty and mastoidectomy. After surgery, she presented with left ocular pain and visual loss. Neurologic examination revealed ptosis, total ophthalmoplegia, and a relative affer...
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
Publication date: Available online 21 June 2019Source: Personalized Medicine UniverseAuthor(s): Kasumi Satoh, Tomoki Furuya, Manabu Okuyama, Hajime NakaeAbstractA 40-year-old man was admitted to the hospital with multiple injuries, including head injury and his laboratory results were significant for sodium abnormalities. Initially, hypernatremia was from increased sodium intake. Subsequently, hyponatremia developed that was unresponsive to sodium supplementation. Syndrome of inappropriate antidiuretic hormone secretion or cerebral salt wasting syndrome was suspected. Additional tests suggested post-traumatic hypopituitari...
Source: Personalized Medicine Universe - Category: Drugs & Pharmacology Source Type: research
Rationale: X-linked nephrogenic diabetes insipidus (NDI) is a rare inherited disease, and is characterized by renal resistance to arginine vasopressin (AVP). Its diagnosis can be clinically challenging. The application of molecular genetic analysis can provide a rapid and definitive diagnosis. Patient concerns: A 75-year-old woman presented with recurrent nausea and vomiting was admitted to the Department of Gastroenterology. The patient had a strong family history of polydipsia and polyuria. Sequencing analysis of the antidiuretic hormone arginine vasopressin receptor 2 (AVPR2) revealed the novel missense mutation p....
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
CONCLUSIONSurgeons should be aware of the persistent renal defects caused by long term lithium use and development of nephrogenic diabetes insipidus even years after medication cessation.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Date: March 25, 2019 Issue #:  1568Summary:  The FDA has approved a sublingual tablet (Nocdurna– Ferring) and a nasal spray (Noctiva– Avadel) formulation of desmopressin acetate for treatment of nocturia due to nocturnal polyuria in adults who wake up ≥2 times per night to void.Nocdurna andNoctiva are the first two products to be approved in the US for this indication. Higher-strength nasal spray and oral tablet formulations of desmopressin (DDAVP, and others) have been available for years for treatment of diabetes insipidus and primary nocturnal enuresis (bedwetting in children)...
Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Source Type: research
More News: Bed Wetting | Diabetes | Diabetes Insipidus | Endocrinology | Enuresis