Community-based Tuberculosis Tracing and Preventive Therapy

Condition:   Tuberculosis Intervention:   Other: Screening and initiating preventive therapy in communities Sponsors:   Elizabeth Glaser Pediatric AIDS Foundation;   Epicentre;   University of Sheffield;   Institut de Recherche pour le Developpement Not yet recruiting
Source: - Category: Research Source Type: clinical trials

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This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
han Wouters Mycobacterium tuberculosis is still the deadliest bacterial pathogen worldwide and the increasing number of multidrug-resistant tuberculosis cases further complicates this global health issue. M. tuberculosis phosphoserine phosphatase SerB2 is a promising target for drug design. Besides being a key essential metabolic enzyme of the pathogen’s serine pathway, it appears to be involved in immune evasion mechanisms. In this work, a malachite green-based phosphatase assay has been used to screen 122 compounds from an internal chemolibrary. Trisubstituted harmine derivatives were found among the best h...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 17 January 2020Source: The Lancet Respiratory MedicineAuthor(s): Thomas J Scriba, Simon C Mendelsohn
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 17 January 2020Source: The Lancet Respiratory MedicineAuthor(s): Rishi K Gupta, Carolin T Turner, Cristina Venturini, Hanif Esmail, Molebogeng X Rangaka, Andrew Copas, Marc Lipman, Ibrahim Abubakar, Mahdad NoursadeghiSummaryBackgroundMultiple blood transcriptional signatures have been proposed for identification of active and incipient tuberculosis. We aimed to compare the performance of systematically identified candidate signatures for incipient tuberculosis and to benchmark these against WHO targets.MethodsWe did a systematic review and individual participant data meta-analysis. We sea...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
The objective of this study was to characterize serological reactivity profiles generated by cattle, American bison, and African buffaloes in tuberculosis. Serum samples from M. bovis-infected animals were tested for the presence of IgM and IgG antibodies to MPB70/MPB83 and CFP10/ESAT6 chimeric proteins using Dual-Path Platform technology. All three host species showed IgG responses of higher magnitude and frequency than IgM responses; further, IgM seroreactivity was limited to MPB70/MPB83, whereas IgG antibodies recognized both test antigens. In cattle, the IgM and IgG responses were elicited mainly by MPB70/MPB83, wherea...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
In the original publication of this article [1] we noticed the Fig.  4 was incorrect. The correct Fig. 4 is as below.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
AbstractIn the current study, a novel combinatorial library of substituted 1,2,4-oxadiazoles bearing pyridine and thiazole have been synthesized via the condensation reaction of amidoxime and carboxylic acids and its derivatives in two way. The titled compounds were screened for their in vitro antimicrobial activity against three gram positive bacteria and three gram negative bacteria, In vitro antituberculosis activity againstMycobacterium tuberculosis H37RV and in vitro antimalarial activity againstPlasmodium falciparum. Majority of the compounds were found to be active against gram positive bacteria. Compounds6e, 6f, 7e...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
CONCLUSION: A high-quality child-friendly FDC water-dispersible tablet was developed improving the treatment of TB in pediatric. PMID: 31944867 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
We report two cases of unilateral iris granulomata in two young patients who presented with decreased vision and redness and were found to have well-circumscribed iris granulomas. Both underwent systemic evaluation and had a negative Mantoux test. Biopsy pathology of the lesions revealed granulomatous inflammation but were negative for PCR, staining, and culture for TB. One patient turned out to have multiple pulmonary lesions. The ocular condition initially worsened with steroid therapy alone and improved and resolved completely after starting a 9 months course of anti-tubercular therapy (ATT). PMID: 31944133 [PubMed ...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
In this study, we analyzed 677,423 human body temperature measurements from three different cohort populations spanning 157 years of measurement and 197 birth years. We found that men born in the early 19th century had temperatures 0.59°C higher than men today, with a monotonic decrease of -0.03°C per birth decade. Temperature has also decreased in women by -0.32°C since the 1890s with a similar rate of decline (-0.029°C per birth decade). Although one might posit that the differences among cohorts reflect systematic measurement bias due to the varied thermometers and methods used to obtain temperatures, we...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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