Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

ConclusionsWe demonstrate that18F-ICMT-11 can be used to detect caspase-3 activation in a death-switch tumour model, independent of the confounding effects of cancer therapeutics, thus confirming its specificity and supporting the development of this radiotracer for clinical use to monitor tumour apoptosis and therapy response.
Source: EJNMMI Research - Category: Radiology Source Type: research