Updates on Corneal Xenotransplantation

This article reviews current knowledge of the antigenicity and bio-physical properties of pig corneal grafts in corneal xenotransplantation, including efficacy and safety data of corneal xenotransplantation using genetically engineered (GE) or wild-type (WT) porcine grafts and decellularized porcine grafts in nonhuman primates as a proof-of-concept. Recent advances in regulatory issues and standardization of protocols for their use are also discussed to help facilitate clinical trials of corneal xenotransplantation in the future.SummaryThis review posits that a proof-of-concept opportunity exists in certain breeds of pigs on corneal xenotransplantation, suggesting feasibility as an alternative option of corneal allotransplantation.
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research