Post-abortion hysteroscopic evaluation – A way to prevent long term complications

Introduction: Either appearing after miscarriage or abortion by request, the trophoblastic retention is often easy to diagnose, but the management can be difficult. Therefore, severe consequences may appear: endometritis, infertility, intrauterine adhesions, persistent molar pregnancy.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Oral Poster at Breakfast 7 – EARLY PREGNANCY LOSS and ECTOPIC Source Type: research

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ConclusionYounger age, earlier treatment within disease course, fewer cervical canal adhesions, and fewer surgical procedures improve reproductive outcome in patients with severe IUAs and amenorrhea.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
AbstractAsherman ’s Syndrome (AS) is an acquired condition defined by the presence of intrauterine adhesions (IUA) that cause symptoms such as menstrual abnormalities, pelvic pain, infertility, recurrent miscarriage, abnormal placentation and attendant psychological distress. Classically, AS is considered an iatro genic disease triggered by trauma to the pregnant uterus. Different factors can cause the destruction of the endometrium, thus affecting the endometrial stem cell niche and creating IUAs. Curettage of the pregnant uterus appears to be the most common source of this destruction. Nevertheless, some AS cases h...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Asherman ’s syndrome (AS) is a typical injury disease with endometrial fibrosis as main pathological manifestation. It is one of the main causes of female infertility associated with endometrial dysfunction, resulting in implantation difficulties, miscarriage and other adverse pregnancy outcome. Studies ha ve found that damage to endometrial basalis directly affect the endometrial regeneration, therefore, intrauterine adhesions are also considered as an endometrial stem cells absence or regenerative dysfunction related diseases.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Elevated NF-κB signaling in Asherman syndrome patients and animal models. Oncotarget. 2017 Jan 27;: Authors: Wang X, Ma N, Sun Q, Huang C, Liu Y, Luo X Abstract Asherman syndrome (intrauterine adhesion) is often associated with menstrual abnormalities, infertility and recurrent miscarriage in female. Currently the molecular mechanism regulating the pathogenesis of Asherman syndrome is not known. Here we revealed that the inflammatory factor NF-κB expression is significantly elevated in the endometrial samples of Asherman syndrome patients. To further study the molecular mechanisms, we estab...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
CONCLUSIONS: This systematic review suggests a link between TOP and adhesion formation, but, according to the scientific literature and despite new diagnostic facilities, the relationship between the methods of TOP and IUA formation remains unclear. Nevertheless, the reported frequency is in accordance with that found in women following D&C for miscarriage. Further research is required. PMID: 27436757 [PubMed - in process]
Source: The European Journal of Contraception and Reproductive Health Care - Category: Reproduction Medicine Authors: Tags: Eur J Contracept Reprod Health Care Source Type: research
One of the hardest things for an infertile couples to deal with is a miscarriage after an IVF cycle . While not getting pregnant can be heartbreaking , losing a pregnancy after getting pregnant is far worse . Sadly, IVF does not provide any protection against miscarriage , and just like a natural pregnancy has a miscarriage rate of about 10% , so does an IVF pregnancy . The loss is far more acute, because this is such a deeply desired pregnancy . A miscarriage can often be the last straw which breaks the camel' s back , and many patients will give up after this. This is a shame, because the fact that you have got pregnant ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
CONCLUSIONS: This appears to be the first documentation of IUA that were entirely attributable to the index miscarriage or its management. There appears to be an increased risk of IUA following D&C with larger uteri and multiple pregnancies and following mechanical suction D&C. PMID: 27261221 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
This study was funded by the Spanish Ministry of Science and Innovation (SAF 2012-31017, Principal Investigator C.S.), Spanish Ministry of Health (EC11-299, Principal Investigator C.S.) and Regional Valencian Ministry of Education (PROMETEOII/2013/018, Principal Investigator C.S.). Four authors (X.S., I.C., A.P. and C.S.) are co-inventors of the patent resulting from this work (Application number: 62/013,121). S.C., C.A., F.R., J.F., J.P. and J.R. have no conflict of interest in relation to this work. TRIAL REGISTRATION NUMBER This study was registered with (NCT02144987).
Source: Human Reproduction - Category: Reproduction Medicine Authors: Tags: Reproductive biology Source Type: research
Authors: Carranza-Mamane B, Havelock J, Hemmings R, Reproductive Endocrinology and Infertility Committee, Cheung A, Sierra S, Carranza-Mamane B, Case A, Dwyer C, Graham J, Havelock J, Hemmings R, Liu K, Murdock W, Vause T, Wong B, Special Contributor, Burnett M Abstract Objective: To provide recommendations regarding the best management of fibroids in couples who present with infertility. Usual and novel treatment options for fibroids will be reviewed with emphasis on their applicability in women who wish to conceive. Options: Management of fibroids in women wishing to conceive first involves documentation of the p...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Conclusion: Hysteroscopic adhesiolysis in patients with moderate Asherman’s syndrome before ICSI restores the anatomy of the uterine cavity and the menstrual blood flow and optimizes the patients’ chances during ICSI, compared with patients with normal uterine cavities; however, their clinical pregnancy rates after correction may be significantly lower.
Source: Journal of Evidence-Based Womens Health Journal Society - Category: OBGYN Tags: Original articles Source Type: research
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