Elevated Pre-Transplant Left Ventricular End Diastolic Pressure Increases Primary Graft Dysfunction Risk in Double Lung Transplant Recipients

Primary graft dysfunction (PGD) is the most important contributor to early morbidity and mortality in lung transplant recipients and reflects a combination of allograft ischemia-reperfusion injury, vasogenic pulmonary edema and inflammatory changes mediated by the innate immune system.1,2,3 Patients who develop PGD are at increased risk of poor lung function and death.4-6 There are limited therapeutic options available to patients who develop PGD after lung transplantation and as such, the main focus has been on the identification of risk factors for PGD and prevention strategies.

Source: The Journal of Heart and Lung Transplantation - February 18, 2019 Category: Transplant Surgery Authors: David Li, Justin Weinkauf, Alim Hirji, Ali Kapasi, Dale Lien, Jayan Nagendran, Daniel Kim, Justin Ezekowitz, Kieran Halloran Tags: Original Clinical Science Source Type: research