Epidermis Activated Gsdma3 Enhances Thermogenesis of Brown Adipose Tissue through Interleukin-6/Stat3 Signaling

Missense mutations in the Gasdermin-A3 (Gsdma3) gene are associated with skin inflammation and hair loss in mice. However, the physiological function of Gsdma3 remains unclear. Here we reported that mice carrying the Gsdma3 Y344H mutation that encodes a presumptive activated form of Gsdma3, show increased heat production along with lower body fat percentages. Detailed analysis indicated that this metabolic phenotype is mediated by serum interleukin-6 –induced up-regulation of thermogenesis in brown adipose tissue.

Source: American Journal of Pathology - February 18, 2019 Category: Pathology Authors: Qin Chen, Peiliang Shi, Dingyu Wang, Qiyao Liu, Xu Li, Yufang Wang, Dayuan Zou, Zan Huang, Xiang Gao, Zhaoyu Lin Tags: Regular article Source Type: research