Hippocampal subfield-specific connectivity findings in major depressive disorder: A 7 Tesla diffusion MRI study

ConclusionsIncreased MD of tracts in the fimbriae suggests compromised neuronal membranes in the major hippocampal output gate. Reduced SC of the dentate gyri indexes a disruption of normal cellular processes such as neurogenesis. These findings may have significant implications for identifying biomarkers of MDD and elucidating the neurobiological underpinnings of depression.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research