Targeting the hydrophobic channel of NNIBP: Discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus

Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00032A, Paperxia Zhong Zhou, Tao Liu, Gaochan Wu, Dongwei Kang, Zhipeng Fu, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu Enlightened by our previous efforts to modify diarylpyrimidines as HIV-1 non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) and the reported crystallographic studies, we designed and synthesized novel 1,2,3-triazole-derived diarylpyrimidine derivatives via... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - February 18, 2019 Category: Molecular Biology Authors: xia Zhong Zhou Source Type: research