Combined T1-mapping and tissue tracking analysis predicts severity of ischemic injury following acute STEMI —an Oxford Acute Myocardial Infarction (OxAMI) study

AbstractEarly risk stratification after ST-segment –elevation myocardial infarction (STEMI) is of major clinical importance. Strain quantifies myocardial deformation and can demonstrate abnormal global and segmental myocardial function in acute ischaemia. Native T1-mapping allows assessment of the severity of acute ischemic injury, however its cli nical applicability early post MI is limited by the complex dynamic changes happening in the myocardium post MI. We aimed to explore relationship between T1-mapping and feature tracking imaging, to establish whether combined analysis of these parameters could predict recovery after STEMI. 96 STEMI p atients (aged 60 ± 11) prospectively recruited in the Oxford Acute Myocardial Infarction (OxAMI) study underwent 3T-CMR scans acutely (within 53 ± 32 h from primary percutaneous coronary intervention) and at 6 months (6M). The imaging protocol included: cine, ShMOLLI T1-mapping and late g adolinium enhancement (LGE). Segments were divided in the infarct, adjacent and remote zones based on the presence of LGE. Peak circumferential (Ecc) and radial (Err) strain was assessed using cvi42 software. Acute segmental strain correlated with segmental T1-mapping values (T1 vs. Err − 0.75  ± 0.25, p <  0.01; T1 vs. Ecc 0.72 ± 0.32, p <  0.01) and with LGE segmental injury (LGE vs. Err − 0.56 ± 0.29, p <  0.01; LGE vs. Ecc 0.54 ± 0.35, p <  0.01). Moreover, acute segmental T1 and s...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research