Mechanical insights into the regulation of programmed cell death by p53 via mitochondria

Publication date: Available online 18 February 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Kohji Yamada, Kiyotsugu YoshidaAbstractAll organisms end with their death, and many parts of cells die through intrinsic suicide machineries in response to diverse stimuli. These intrinsic cell death pathways are often termed as programmed cell deaths (PCDs), and are critical for organism development, tissue homeostasis and various diseases. Recent evidence has revealed that most of PCDs involve a tumor suppressor p53 and components of the intra-mitochondria. Furthermore, the movement and positioning of p53 in cells affect the induction of each PCD pathway. Here we provide a comprehensive review on p53-related PCD mechanisms via the mitochondria, namely classical apoptosis, non-classical apoptosis, autophagic cell death, ferroptosis, necroptosis. In addition, we discuss the roles of p53 in each PCD pathway by focusing its altered intracellular localization in response to diverse cellular stresses.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research

Related Links:

Publication date: Available online 16 October 2019Source: Journal of Psychiatric ResearchAuthor(s): Aline Ribeiro Borçoi, Suzanny Mendes de Oliveira, Joaquim Gasparini dos Santos, Mayara Mota de Oliveira, Ivana Alece Moreno Arantes, Flávia Vitorino Freitas, Júlia Assis Pinheiro, Juliana Krüger Arpini, Ester Ribeiro Cunha, Anderson Barros Archanjo, Aricia Leone Evangelista Monteiro de Assis, Bruna Pereira Sorroche, Lídia Maria Rebolho Batista Arantes, Elizeu Borloti, Adriana Madeira Álvares-da-SilvaAbstractObjectiveThe aim of this study was to verify determinant factors for depression...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
[This Day] Parents, teachers and school managers recently converged on the Main Auditorium, Lagos Business School for the second edition of the Olashore International School mental wellness programme, aimed at promoting awareness of the incidence of suicide among youths in the country and provide guides to tackle the challenges.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
INTRODUCTION: Investigation in each community can contribute to understanding the key factors involved in suicide death and its prevention. The present study aimed to investigate suicide death risk factors based on psychological autopsy method. MET...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
This study explore...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
BACKGROUND: Psychiatric disorders are reported to be present in 80% to 90% of suicide deaths in high-income countries (HIC), but this association is less clear in low- and middle-income countries (LMIC). There has been no previous systematic review of this...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
BACKGROUND: Little is known about the neural substrates of suicide risk in mood disorders. Improving the identification of biomarkers of suicide risk, as indicated by a history of suicide-related behavior (SB), could lead to more targeted treatments to red...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Gishen ’s thoughts on mental wellbeing among medical students are refreshing.1 An area that has a huge impact on student wellbeing is isolation. Moving between wards—sometimes weekly—can provoke anxiety, but having to travel long distances and ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Young Adults Source Type: news
Gishen ’s call for discussion around suicide in medical students is long overdue.1 As a profession, we need to acknowledge that mental health problems are not solely the burden of the qualified. Simply relocating from your hometown at the age of 18 ca...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Young Adults Source Type: news
The purpose of this paper is to provide a review of law enforcement suicide research from 1997 to 2016. Design/methodology/approach The PRISMA systematic review methodology was implemented. A SCOPUS search identified a total of 97 documents. After a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Aims: To determine the extent of DNA methylation of parvalbumin gene (PVALB) promoter in major depressive disorder (MDD) patients with and without suicide attempt in comparison with healthy controls. Methods: The extracted DNA from dri...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
More News: Depression | Mitochondria | Molecular Biology | Suicide