New pill to halt agony of arthritis: Revolutionary tablet may stop pain for millions

A GAME-CHANGING daily pill to treat the most common form of arthritis could soon be available for millions of Britons. Scientists are testing the drug, known as APPA, on humans after finding that it significantly relieves osteoarthritis pain in animals.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Publication date: 23 May 2019Source: Journal of Ethnopharmacology, Volume 236Author(s): Cheryl LansAbstractEthnopharmacological relevanceThere are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset t...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionMDHAQ/RAPID3 scores are similar in OA or RA at initial visit, but higher in OA 6 months later, reflecting superior RA treatments. The same MDHAQ/RAPID3 allows comparisons of disease burdens in different diseases.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
AbstractObjectiveThe TRIUMPH study assessed the efficacy and safety of high ‐purity synthetictrans‐capsaicin (CNTX‐4975) in subjects with chronic osteoarthritis‐associated moderate to severe knee pain.MethodsIn this double ‐blind, multicenter, phase 2 study, subjects aged 45–80 years with stable knee osteoarthritis were randomized in a 2:1:2 ratio to receive a single, intra‐articular injection of placebo, CNTX‐4975 0.5 mg, or CNTX‐4975 1.0 mg. The primary efficacy endpoint was area under the curve (AUC) for change from baseline in daily Western Ontario and McMaster Universities Osteoarthritis Index (W...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Conditions:   Shoulder Pain;   Shoulder Osteoarthritis;   Shoulder Arthritis Interventions:   Device: Stemmed shoulder arthroplasty, Biomet Comprehensive® Total Shoulder System.;   Device: Stemless shoulder arthroplasty, Biomet Comprehensive® Nano Shoulder System. Sponsors:   Zealand University Hospital;   Hvidovre University Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
THURSDAY, March 14, 2019 -- Knee pain is not associated with daily walking levels in individuals with mild-to-moderate, symptomatic knee osteoarthritis (KOA), according to a study published online March 6 in Arthritis Care&Research. Nicholas...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
(Reuters Health)—Patients with knee osteoarthritis (OA) can add hip-strengthening exercises to their workout to improve the ability to walk and maybe reduce pain, according to a research review. Based on pooled data from eight clinical trials with a total of 340 patients, hip strengthening exercises involving weights or elastic bands would help the most, the... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Osteoarthritis Exercise hip knee Knee Osteoarthritis (OA) knee pain walking weight training Source Type: research
Patients with knee osteoarthritis can add hip-strengthening exercises to their workout to improve the ability to walk and maybe reduce pain, according to a research review.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news
Authors: Biazzo A, Manzotti A, Confalonieri N Abstract The purpose is to demonstrate that Bi-Unicom- partmental knee arthroplasty (Bi-Uni) can produce equivalent long-term outcomes to total knee arthroplasty (TKA) in patients with bicompartmental knee osteoarthritis involving both the medial and lateral tibio-femoral compartments. A total of 37 patients with bicompartmental tibio- femoral osteoarthritis of the knee treated between January 1999 and March 2005 underwent either Bi-Uni or TKA. Nineteen patients who underwent simultaneous implantation of 2 unicompartmental knee arthroplasties (UKA) were matched and comp...
Source: Acta Orthopaedica Belgica - Category: Orthopaedics Tags: Acta Orthop Belg Source Type: research
Abstract The basal joint of the thumb (articulatio carpometacarpalis pollicis) is the joint of the hand most frequently affected by arthritis. Arthritis of the basal joint of the thumb typically occurs in the second half of life and more frequently in women. The clinical symptoms are pain, joint swelling, reduced strength and limited hand function with a reduced hand span. When clinical symptoms first appear a conservative treatment is initially indicated. If these measures do not lead to an improvement of the complaints, various operative measures are possible depending on the stage of the disease detected by rad...
Source: Der Orthopade - Category: Orthopaedics Authors: Tags: Orthopade Source Type: research
ObjectiveThe neural mechanisms of pain in knee osteoarthritis (OA) are not fully understood, and some patients have neuropathic ‐like pain associated with central sensitization. To address this, we undertook the present study in order to identify central sensitization using neuroimaging and PainDETECT and to relate it to postarthroplasty outcome.MethodsPatients awaiting arthroplasty underwent quantitative sensory testing, psychological assessment, and functional magnetic resonance imaging (fMRI). Neuroimaging (fMRI) was conducted during punctate stimulation (n = 24) and cold stimulation (n = 20) to the affected knee. The...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
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