Oral administration of a mixture of probiotics protects against food allergy via induction of CD103+ dendritic cells and modulates the intestinal microbiota

In this study, we aimed to evaluate the effect of a mixture of probiotics on food allergy in an ovalbumin (OVA)-induced murine model. Treatment with the probiotics attenuated OVA-induced allergic symptoms in mice. Flow cytometry analysis showed that oral administration of probiotics induced mucosal CD103+ dendritic cells (DCs), which promoted differentiation of regulatory T cells (Tregs). 16S rRNA analysis revealed that the probiotics modulated the composition of microbiota, especially by increasing the proportion of the Deferribacteres and Verrucomicrobia phyla and the Mucispirillum and Clostridium XlVa genera, which in turn regulated the immune system. Our findings provide molecular insight into the application of a mixture of probiotics to alleviate food allergies and even gut immune homeostasis.Graphical abstractThe probiotics interacted with the gut microbiota and regulated the CD103+DC accumulation, which impacted the induction of regulatory T cells in PPs and MLNs. The protective effects of the probiotics on food allergies may be by promoting the reconstruction of oral tolerance through their role in regulating gut microbiota and the immune system.
Source: Journal of Functional Foods - Category: Nutrition Source Type: research