Evaluation of Healthy User Effects With Metformin and Other Oral Antihyperglycemia Medication Users in Adult Patients With Type 2 Diabetes

ConclusionsOur results suggest that metformin users are more likely to initiate preventive therapies and engage in other healthy behaviours. Failure to account for these behaviours may introduce healthy user bias into studies evaluating the effects of oral antihyperglycemic therapies.RésuméObjectifsLe biais lié aux utilisateurs sains selon lequel les patients ayant recours aux soins de santé sont plus susceptibles d'entreprendre des traitements préventifs et d'adopter des comportements sains liés au mode de vie est bien connu dans les études observationnelles, particulièrement en ce qui concerne les statines. Dans les études portant sur les traitements antihyperglycémiants par voie orale, son influence demeure toutefois inconnue. Nous avons cherché à explorer les effets liés aux utilisateurs sains entre les utilisateurs et les non-utilisateurs de metformine sur les divers résultats cliniques qui devraient être associés à l'utilisation de la metformine.MéthodesNous avons mené une étude de cohorte rétrospective à partir des données de l'Alberta, entre 2008 et 2015, pour examiner l'association entre l'utilisation de la metformine et les divers résultats cliniques.RésultatsParmi les 135 301 nouveaux utilisateurs d'antihyperglycémiants par voie orale, 75 949 (56%) étaient ...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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CONCLUSION: ATV inhibited ROS generation and activated IL-1 β/IL-6 secretion in PBMNC of diabetes patients. Its effect was not affected by the hyperglymemia. PMID: 31416412 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Authors: Phan K, Smith SD Abstract Background: Topical steroids have been previously associated with potential for hyperglycemia and glucosuria, and thought to have a relatively safe side effect profile. In prolonged use, there is the potential for steroids to be absorbed through the skin and eventually reach systemic circulation. We aimed to investigate the potential association between topical corticosteroid use and development of diabetes, we performed a systematic review and meta-analysis of available case-control data in the literature. Methods: Electronic database searches was performed to identify studies co...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Conclusion: IP-10 and MCP-1 AH levels seem to be related to DEX intraocular action, decreasing after injection and increasing when DME relapses. In addition, IL-6 and IL-8 may play a role in DME late evolution and clinical relapse beyond DEX effect. PMID: 31418610 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
CONCLUSION: This study showed positive workplace culture change associated with the quality improvement intervention. Lessons learned from the implementation of this program can inform future quality improvement initiatives. PMID: 31416705 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Sport and Health ScienceAuthor(s): Carlos Cristi-Montero, Javier Courel-Ibáñez, Francisco B Ortega, Jose Castro-Piñero, Alba Santaliestra Pasias, Angela Polito, Jérémy Vanhelst, Ascensión Marcos, Luis M Moreno, Jonatan R Ruiz, HELENA study groupAbstractPurposeTo analyze the mediation role of cardiorespiratory fitness (CRF) on the association between fatness and cardiometabolic risk (CMRs) in European adolescents.MethodsA cross-sectional study was conducted in adolescents (n = 525; boys 46%; 14.1 ± 1.1 ye...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Evaluating the Lipid-Lowering Effects of α-lipoic Acid Supplementation: A Systematic Review. J Diet Suppl. 2019 Aug 15;:1-15 Authors: Erickson N, Zafron M, Harding SV, Marinangeli CPF, Rideout TC Abstract Dietary supplementation of α-lipoic acid, an 8-carbon organosulfur compound, has been widely reported to lower blood glucose concentration and/or improve insulin sensitivity in previous randomized controlled trials. Although animal model studies further report fairly consistent lipid lowering in both blood and tissue pools in response to α-lipoic acid supplementation, results from hu...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
Publication date: Available online 16 August 2019Source: Social Science &MedicineAuthor(s): Marian KrawczykAbstractHospitals remain the most common location of death in a significant number of countries, and specialist palliative care is positioned as a crucial resource for improving hospital care for those nearing end of life. Little is known, however, about a substantive aspect of this work: how hospital palliative clinicians anticipate and organize a patient's dying trajectory. In this paper I draw from a larger original ethnographic research study of palliative specialists in two Canadian hospitals. Abductive analy...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Authors: Tan K, Chow WS, Leung J, Ho A, Ozaki R, Kam G, Li J, Choi CH, Tsang MW, Chan N, Lee KK, Chan KW PMID: 31416990 [PubMed - in process]
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
Publication date: Available online 16 August 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Oana Onisie, Hamish Crocket, Martin de Bock
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
This article explores the most relevant issues facing the role of e-Health and its sub-category—mobile health (mHealth)—in promoting treatment adherence in childhood asthma, focusing on current evidence gaps and limitations, and future research perspectives.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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