A minimalist's approach for DNA nanoconstructions.

A minimalist's approach for DNA nanoconstructions.
Adv Drug Deliv Rev. 2019 Feb 12;:
Authors: Zuo H, Mao C
Abstract
Structural DNA nanotechnology takes DNA, a biopolymer, far beyond being the molecule that stores and transmits genetic information in biological systems. DNA has been employed as building blocks for the assembly of designed, nanoscaled, supramolecular DNA architectures for applications in biophysics, structure determination, synthetic biology, diagnostics, and drug delivery. Herein, we review a symmetric approach of tile-based DNA self-assembly. This approach allows construction of DNA nanostructures from minimal numbers of different types of DNA strands based on sequence and structural symmetries. Some examples of the applications of this approach in siRNA delivery are discussed as well.
PMID: 30769045 [PubMed - as supplied by publisher]

Source: Advanced Drug Delivery Reviews - February 12, 2019 Category: Drugs & Pharmacology Authors: Zuo H, Mao C Tags: Adv Drug Deliv Rev Source Type: research