Multifocal pulmonary mucinous cystic neoplasm with ovarian-like stroma: Once in a blue moon-case report

Publication date: Available online 16 February 2019Source: Respiratory Medicine Case ReportsAuthor(s): Sarah Shawash, Riad Abdeljalil, Hussam HaddadAbstractMucinous cystic neoplasm of the lung is a rare well known entity in the WHO classification of lung tumors. It is defined as “a localized cystic mass filled with mucin and surrounded by a fibrous wall lined by well-differentiated columnar mucinous epithelium.” The presence of ovarian-like stroma is not mentioned in this definition. Reviewing the literature, we have found only one reported case mentioning this finding, described by Geramizadeh et al., in 2014. Here we present a similar case of a patient who was initially thought to have lung metastases. Hence, our case is the second one to be reported in the literature.After gross dissection of the received specimens, microscopic examination was performed. The H&E slides revealed that the lesions are composed of non-infiltrarive biphasic proliferation of benign mucious epithelial cells forming cysts and gland-like structures with intervening cellular ovarian-like stroma. Differantial diagnosis included hamartoma and sclerosing pneumocytoma. Additionally, ancillary studies were performed including cytokeratin AE1/AE3, EMA, TTF-1, MUC5AC, ER, CD10, SMA, CD34, S100, Inhibin, PAS, PAS/D and Mucicarmine.Immunohistochemistry showed Cytokeratin AE1/AE3, EMA and TTF-1 are positive in the epithelial cells and negative in the stromal cells. MUC5AC is weakly positive at the surface...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research