Macrophages on Bone Homeostasis.

Macrophages on Bone Homeostasis. Curr Stem Cell Res Ther. 2019 Feb 14;: Authors: Kong L, Wang Y, Smith W, Hao D Abstract Aberrant or prolonged immune responding has been proved involved in bone homeostasis. As a component of the innate immune system, macrophages play a critical role in bone homeostasis. Conventionally, according to response to various panel of stimuli, macrophages can be plastically classified as two major phenotypes: M1 and M2. M1 macrophages are generally pro-inflammatory, whereas M2 are anti-inflammatory. Although studies demonstrated both M1 and M2 phenotypes have been implicated in various inflammatory bone diseases, their direct role in bone homeostasis remains exploring. Thus, in this review we briefly discuss the term of "osteoimmunology", which deals with the crosstalk and shared mechanisms of the bone and immune systems. Besides that, we overview the M1 and M2 macrophages for their role in osteoclastogenesis and osteogenesis as well as relevant signaling cascades involved. PMID: 30767753 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research