Obesity and laboratory aspirin resistance in high-risk pregnant women treated with low-dose aspirin

Low-dose aspirin (LDA) is used for preeclampsia (PE) prevention in high-risk women, but the precise mechanism and optimal dose are unknown. Evidence suggests that an imbalance in prostacyclin and thromboxane A2 (TXA2) plays a key role in the pathogenesis of PE. Aspirin has a dose-dependent effect blocking production of TXA2, a potent stimulator of platelet aggregation and promoter of vasoconstriction. Incomplete inhibition of platelet aggregation, designated aspirin resistance, can be reduced by increasing the aspirin dose.

Source: American Journal of Obstetrics and Gynecology - February 17, 2019 Category: OBGYN Authors: Matthew M. Finneran, Veronica M. Gonzalez-Brown, Devin D. Smith, Mark B. Landon, Kara M. Rood Tags: Original Research Source Type: research