Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them

Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them J Clin Res Pediatr Endocrinol. 2019 Feb 14;: Authors: Kiebzak GM, Neal KM, Hossienzadeh P, Olney RC, Levine MA Abstract Reports suggesting that vitamin D may have extraskeletal roles have renewed interest in vitamin D research and stimulated publication of an increasing number of new studies each year. These studies typically assess vitamin D status by measuring the blood concentration of 25-hydroxyvitamin D (25[OH]D), the principal circulating metabolite of vitamin D. Unfortunately, variations in assay format, inconsistency in interpreting 25(OH)D concentrations, cohort bias (age, BMI, race, season of measurements etc.) and failure to measure critical variables needed to interpret study results, makes interpreting results and comparing studies difficult. Further, variation in reporting results (reporting mean values vs. percent of the cohort that is deficient, no clear statement as to clinical relevance of effect size, etc.) further limits interstudy analyses. In this paper, we discuss many common pitfalls in vitamin D research. We also provide recommendations on avoiding these pitfalls and suggest guidelines to enhance consistency in reporting results. PMID: 30759962 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

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Authors: Minkowitz B, Sawyer A, Fung EB, Dvorzhinskiy A, Lane JM Abstract Vitamin D is necessary for the regulation of calcium and phosphate in the human body. Decreased vitamin D levels can alter the bone mineralization process. The prevalence of vitamin D deficiency in the general population is high, and low vitamin D levels are associated with disorders such as rickets and osteoporosis. As knowledge about vitamin D metabolism increases, physicians of all specialties are becoming more attentive to the vitamin D status of their patients. Similarly, orthopaedic surgeons, through various initiatives such as "Ow...
Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
In conclusion, our study provides a novel evidence of a significant positive association of sufficient 25(OH)D levels with the stability of the disease and a satisfactory repigmentation process in Caucasian adult vitiligo patients and strengthen the need to assess vitamin D status in vitiligo. The correlation between sufficient vitamin D levels and a satisfactory course of the disease opens the way for future randomized controlled trials assessing a possible beneficial role of vitamin D supplementation on vitiligo. PMID: 31414974 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Authors: Wang W, Gao Y, Liu H, Feng W, Li X, Guo J, Li M Abstract Cyclophosphamide (CTX) as an alkylating agent is used for treating a range of tumor types and allergic diseases. However, high-dose application may induce rapid bone loss and increase the risk of osteoporotic fractures. Eldecalcitol (ED-71), a clinically approved active vitamin D analog, has been approved for osteoporosis treatment. It potently inhibited bone resorption while maintaining osteoblastic function in estrogen-deficient and high-turnover osteoporosis in model rats. The aim of the present study was to clarify the treatment effect of ED-71 o...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Conclusions25(OH)D3 levels were not associated with brain volume or lesional measures in progressive MS contrary to what has been described in relapsing remitting MS. An association between WB-MTR and NAGM-MTR suggest higher vitamin D levels may exert a protective role on myelin content in progressive MS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We report a patient with severe VDD that resulted in TdP and cardiac arrest. Post-resuscitation work up illustrated prolonged QTc interval of 620 ms, significant hypocalcemia, and severe VDD of 4 (normal 30–80) ng/mL. After high dose vitamin D/calcium supplements, repeat electrocardiogram revealed normal QTc interval of 423 ms. During hospitalization, the patient suffered no additional arrhythmias and QTc continued to be normal.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
This study uses ...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
AbstractVitamin D deficiency has been associated with adverse pregnancy and birth outcomes such as increased risk for preterm birth and preeclampsia. This state of the science review analyzed recently published meta ‚Äźanalyses and relevant studies that have evaluated the association between vitamin D deficiency and preeclampsia or preterm birth. The results suggest that a positive association between vitamin D deficiency and preterm birth exists. However, the findings of the relationship between vitamin D defi ciency and preeclampsia were inconclusive, possibly because of the need for supplementation to occur prior to pla...
Source: Journal of Midwifery and Women's Health - Category: Midwifery Authors: Tags: Review Source Type: research
We have read the recently published article by Kija and colleagues, entitled “Vitamin D abnormalities and bone turn over analysis in children with epilepsy in the Western Cape of South Africa” with great interest [1]. The authors studied the effect of antiepileptic drugs on bone metabolism and found that 16.6% of children with epilepsy and 8.8% healthy children had vitam in D deficiency. We congratulate the authors for their excellent work and want to add few points.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
ConclusionsThe patients studied mainly had moderate-to-severe CP, with a high frequency of suboptimal VD values and low plasma ferritin; few patients received VD and/or iron supplementation. We suggest monitoring 25(OH)D and ferritin levels due to the high rate of deficiency of these nutrients; public hospitals should be equipped with drugs to treat these deficiencies.ResumenIntroducciónLos niños y adolescentes con parálisis cerebral (PC) tienen mayor riesgo de desnutrición y deficiencias de micronutrientes. Dos de los que podemos estudiar y tratar son la vitamina D (VD) y el hierro. No disponem...
Source: Neurologia - Category: Neurology Source Type: research
VITAMIN D is an essential vitamin that keeps the bones healthy. Growing evidence is shedding a new light on the risks associated with a vitamin D deficiency. One study finds an unsettling link to an increased risk of health problems associated with a vital organ.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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