Hydrative syntheses of amides from alkynes catalyzed by an Au(I) complex containing pyridyl-functionalized NHC ligand

Publication date: Available online 15 February 2019Source: Journal of Organometallic ChemistryAuthor(s): Kuldeep Singh, Nilay Kumar Pal, Chirajyoti Guha, Jitendra K. BeraAbstractAn Au(I)-NHC complex [L1AuBr] (1) with appended pyridyl group on the ligand scaffold is synthesized and its catalytic efficacy for the direct synthesis of the amide from alkyne and sodium azide in acidic water is evaluated. Catalyst 1 readily converts a wide range of internal and terminal alkynes to the corresponding amides with low catalyst loading in TFA/DCE (2 mL, 1:1 v/v) at room temperature in short reaction time (2 h) and without the use of Ag(I) additive. A related catalyst that is devoid of the pyridyl fragment displays significantly lower activity illustrating the role of the promoter ligand for water activation. Mechanistic studies reveal an initial alkyne hydration to ketone followed by the Schmidt reaction to afford the amide.Graphical abstract

Source: Journal of Organometallic Chemistry - February 16, 2019 Category: Chemistry Source Type: research