Proteomic characterization of early lung response to breast cancer metastasis in mice.

CONCLUSION: The analysis enabled revealing the importance of calcium signaling during the early phase of metastasis development, early cytoskeleton and extracellular matrix reorganization, activation of defense mechanisms and metabolic adaptations. It seems that the tissue response is an interplay between pro- and anti-metastatic mechanisms accompanied by inflammation, oxidative stress and dysfunction of the barrier endothelial cells.
PMID: 30763573 [PubMed - as supplied by publisher]

Source: Experimental and Molecular Pathology - February 11, 2019 Category: Pathology Authors: Kurpińska A, Suraj J, Bonar E, Zakrzewska A, Stojak M, Sternak M, Jasztal A, Walczak M Tags: Exp Mol Pathol Source Type: research