Novel antimicrobial agents’ discovery among the steroid derivatives

Publication date: Available online 15 February 2019Source: SteroidsAuthor(s): Nanuli Sh. Nadaraia, Lela Sh. Amiranashvili, Maia Merlani, Meri L. Kakhabrishvili, Nana N. Barbakadze, Athina Geronikaki, Anthi Petrou, Vladimir Poroikov, Ana Ciric, Jarmila Glamoclija, Marina SokovicAbstractFourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Almost all compounds except of compound 4 (3β-acetoxy-1/-p-chlorophenyl-3/-methyl-5α-androstano[17,16-d]pyrazoline) were more potent than Ampicillin, and they were equipotent or more potent than Streptomycine. All compounds exhibited good antifungal activity with MIC at 0.003-0.96 mg/mL and MFC at 0.006-1.92 mg/mL but with different sensitivity against fungi tested. According to docking studies 14-alpha demethylase inhibition may be responsible for antifungal activity. Prediction of toxicity by PROTOX and GUSAR revealed that compounds have low toxicity and can be considered as potential lead compounds for the further studies.Graphical abstractFourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Docking studies were performed ...

Source: Steroids - February 16, 2019 Category: Drugs & Pharmacology Source Type: research